Sourcery · 3 min instead of 1 h 10 m · Oct 14, 2026
Early reasoning models solved hard diagnostic cases doctors often miss
Nworah Ayogu
Partner, Thrive Capital
Physician who ran Amazon Clinic, was Amazon Pharmacy's first chief medical officer and was on Cityblock Health's founding team.
Molly O'SheaHost · Founder, Sourcery
Ex-Upfront Ventures investor; has interviewed Alex Karp and Palmer Luckey.
About this segment
Ayogu tested OpenAI's pre-release reasoning model on New England Journal of Medicine case studies and it got all ten right. Healthcare CEOs called it heresy until they watched it live.
From “Thrive Capital’s Dr. Nworah Ayogu on Why Neuralink Is More Interesting Than SpaceX”, Oct 14, 2026. Watch the full episode
“And they were open AI and the 01 was batting a 10 out of 10, which was amazing to me.”
Nworah Ayoguat 41:38 · Sourcery41:38Takeaways
- Ayogu fed NEJM case studies, cut before the answer, to OpenAI's reasoning model weekly
- The model went 10 for 10 where top doctors might get 2 in 10
- A biotech CEO who dismissed AI for drug discovery now spends billions on it
In this episode
Full episode40:00Early reasoning models solved hard diagnostic cases doctors often miss2:47
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