Real Alpha

Full episode · 33 min

Why AlphaFold Didn't Solve Protein Folding — Pushmeet Kohli, Google DeepMind & Sal Candido, Biohub

Latent Space · Shawn Wang (swyx) & Alessio Fanelli with Pushmeet Kohli and Sal Candido

The best minutes

  1. 3:07Messy metagenomic data can improve protein models3 min

Also worth watching

  1. 15:16AlphaFold reproduces PDB deposits, not true protein dynamics5 min
  2. 24:30Calibrated confidence mattered more for AlphaFold than accuracy4 min

Skip the problem-first career advice and the discussion of handcrafted versus scalable architectures.

Published Oct 10, 2026.

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